Luc BRUNEL graduated from a DEA in heterocycle chemistry, polymers and catalysis obtained at the University of Montpellier in 1997. After several experiences in the private sector, since 2003 he has been working as a CNRS engineer in biomolecule development.
He works on both the SynBio3 platform providing biomolecules of biological interest and pharmaceuticals, as responsible for syntheses and purifications in large quantities, but also within the research team of the laboratory to carry out certain precursor projects.
Luc possesses very solid skills in the fields of peptide synthesis in solution and solid support as well as a 15-year expertise in the implementation and development of peptide purification on preparative HPLC.
Luc obtained the CNRS Crystal medal in 2015.
5 major publications :
In Vivo Stabilization of a Gastrin-Releasing Peptide Receptor Antagonist Enhances PET Imaging and Radionuclide Therapy of Prostate Cancer in Preclinical Studies. Chatalic KL, Konijnenberg M, Nonnekens J, de Blois E, Hoeben S, de Ridder C, Brunel L, Fehrentz JA, Martinez J, van Gent DC, Nock BA, Maina T, van Weerden WM, de Jong M. Theranostics. 2016 Jan 1;6(1):104-17. doi: 10.7150/thno.13580. eCollection 2016.
Gastrin releasing peptide receptor-directed radioligands based on a bombesin antagonist: synthesis, (111)in-labeling, and preclinical profile. Marsouvanidis PJ, Nock BA, Hajjaj B, Fehrentz JA, Brunel L, M’Kadmi C, van der Graaf L, Krenning EP, Maina T, Martinez J, de Jong M. J Med Chem. 2013 Mar 28;56(6):2374-84. doi: 10.1021/jm301692p. Epub 2013 Mar 8.
An innovative strategy for sulfopeptides analysis using MALDI-TOF MS reflectron positive ion mode. Cantel S, Brunel L, Ohara K, Enjalbal C, Martinez J, Vasseur JJ, Smietana M. Proteomics. 2012 Aug;12(14):2247-57. doi: 10.1002/pmic.201100525.
The 1,2,4-triazole as a scaffold for the design of ghrelin receptor ligands: development of JMV 2959, a potent antagonist. Moulin A, Brunel L, Boeglin D, Demange L, Ryan J, M’Kadmi C, Denoyelle S, Martinez J, Fehrentz JA. Amino Acids. 2013 Feb;44(2):301-14. doi: 10.1007/s00726-012-1355-2. Epub 2012 Jul 14. Review.
Synthesis of peptide alcohols on the basis of an O-N acyl-transfer reaction. Tailhades J, Gidel MA, Grossi B, Lécaillon J, Brunel L, Subra G, Martinez J, Amblard M. Angew Chem Int Ed Engl. 2010;49(1):117-20. doi: 10.1002/anie.200904276