Baptiste Legrand

Baptiste legrand
Research Engineer, University of Montpellier (UM)

Baptiste is a Research Engineer at the Institute of Biomolecules Max Mousseron (IBMM), University of Montpellier. He received his PhD in biology and life sciences from the University of Rennes 1 in 2009. Then, he moved for a two years post-doctoral fellowship at the Laboratory of Macromolecular Chemistry and Physics (LCPM, Nancy) working on the characterization of foldamers structures combining various techniques (NMR, CD and FTIR spectroscopies, and Molecular Dynamics) and then he joined the IBMM in 2012. His research is mainly devoted on the rational design of peptidomimetics and organized molecular architectures to modulate biological processes focusing on the structural aspects. He is in charge of the conformational studies of various chemical tools developed at the IBMM but also collaborates with other groups.

+33 411 75 96 06

5 major publications :

Legrand B, André C, Moulat L, Didierjean C, Hermet P, Bantignies JL, Martinez J, Amblard M, Calmès M. 12/14/14-Helix Formation in 2:1 α/β-Hybrid Peptides Containing Bicyclo[2.2.2]octane Ring Constraints. Chemistry. 2016. 16;22(34):11986-90.

Martin V, Legrand B, Vezenkov LL, Subra G, Calmès M, Bantignies J.L, Martinez J,  Amblard M. Turning Peptide Sequences into Ribbon Foldamers by a Straightforward Multicyclization Reaction. Angew. Chem. Int. Ed. 2015. 16;54(47):13966-70.

Legrand B, André C, Moulat L, Wenger E, Didierjean C, Aubert E, Averlant-Petit MC, Martinez J, Calmes M, Amblard M. Unprecedented chain-length-dependent conformational conversion between 11/9 and 18/16 helix in α/β-hybrid peptides. Angew Chem Int Ed. 2014. 53(48):13131-5.

Mathieu L, Legrand B, Deng C, Vezenkov L, Wenger E, Didierjean C, Amblard M, Averlant-Petit MC, Masurier N, Lisowski V, Martinez J, Maillard LT. Helical oligomers of thiazole-based γ-amino acids: synthesis and structural studies. Angew Chem Int Ed. 2013. 3;52(23):6006-10.

Legrand B, André C, Wenger E, Didierjean C, Averlant-Petit MC, Martinez J, Calmes M, Amblard M. Robust helix formation in a new family of oligoureas based on a constrained bicyclic building block. Angew Chem Int Ed. 2012. 51(45):11267-70.