Team Peptide is involved with vulgarisation of science ! It was our pleasure and privilege to receive eight high school teachers from the south of France reagion! At the pictures Laurine Valot, Gilles Subra and Lubomir Vezenkov animating a workshop on 3d printing of peptide materials and solid phase peptide synthesis.
IBMM has recently acquired this wonderful UPLC and mass-spectrometry toy! It is an Aquity Hclass UPLC (Pierre Sanchez to the left, the engeneer that operates it) produced by Waterstm that can sustain the amazing 15000 psi! While other HPLC would crumble under such pressure this fine equipment provides an amazing HPLC separation! Getting to 95% purity just got harder in our team!
The European Medicines Agency (EMA) has granted marketing authorization for MacrilenTM (JMV 1843), an orally available ghrelin agonist developed in our team ! Macrilen is used for diagnosis of adult growth hormone deficiency (AGHD). The approval came following the Committee for Medicinal Products for Human Use (CHMP) positive opinion of MacrilenTM.
People who have AGHD can include those who were GH deficient as children and become adults with AGHD, or adults who become GH deficient. In adults, GH deficiency could develop when your pituitary gland or hypothalamus is damaged due to tumors, surgery, radiation, or traumatic brain injury. GH is important for adults to support healthy tissue and organs. GH is released in pulses, so measuring your blood for too little GH (also known as a deficiency) may be hard. MacrilenTM, orally administered, will stimulate GH secretion in the circulation, which level can then be evaluated by simple blood samples.
Alice Legru, Kévin Bourbiaux, Christophe Cantelli and Yohan Malki attended the 26th Young Research Fellows Meeting which took place on 20th – 22nd February at the Faculty of Pharmacy of Paris. Alice did a great 15 minutes oral communication while and Kévin, Christophe and Yohan presented posters.
Titouan is the laureate of the “Prix Initiative Jeune” of Fondation Banque Populaire du Sud. He received a grant to participate to the “Sol-Gel Conference” congress in St. Petersburg in August. This congress will be an opportunity to present his thesis work.
Happy, healthy and prosperous 2019 to all the members and friends of IBMM peptide team !
The paper of Nicolas is just accepted in Eur. J. Org. Chem.
He took advantage of Surface Enhanced Raman Spectroscopy to design peptide-adenine conjugates as candidates for their use as serine protease substrates.
Thanks to a Merlion grant, Gilles and Laurine spent 2 weeks in Singapore, in Pr. Sing Yian Chew’s lab at the School of Chemical and Biomedical Engineering, Nanyang Technological University. This trip was an opportunity to implant sol-gel based hydrogel scaffolds (with a collagen-like peptide) into rats to assess their ability to repair spinal cord injury.
Gilles was an invited speaker at Korean Peptide Meeting in Yoesu, Korea.
He presented an overview of the work on peptide hydrogels and 3D printing
Cecile worked in the ibmm peptide team during her PhD (2013-2016), in collaboration with Prof. Ahmad Mehdi (ICGM). She worked on the development of hybrid hydrogels for 3D printing and tissue engineering. Now postdoctoral researcher in Heidelberg, she speaks about her PhD in a video realized by Société Chimique de France (SCF). Cecile was distinguished as ‘woman in science’ 2016 by Unesco&L’Oréal for her research work in chemistry.