Design and synthesis of heterocycles for therapeutic applications

Heterocycles for therapeutic applications

Heterocycles are common structural units in marketed drugs and in medicinal chemistry due to the central role they play in modern drug design. Indeed, heterocycles are useful scaffolds that can be decorated with various substituents in order to modulate lipophilicity, polarity, and hydrogen bonding capacity of molecules. These structural modulations may lead to improved pharmacological, pharmacokinetic, toxicological, and physicochemical properties of drug candidates. Heterocycles are also routinely used as bioisosteres for a variety of functional groups in drug candidates. Therefore, heterocycles represent privileged structures in the drug discovery process.

In order to find new potential lead compounds for therapeutic applications, we develop methodologies to access and structurally modulate heterocycle scaffolds such as [1,2,4]triazoles, diazepines, thiazoles and triazole-ketopiperazines.

CONTACT

Nicolas Masurier
Nicolas Masurier
Jean Martinez
Jean Martinez
Séverine Denoyelle
Séverine Denoyelle
Laurent Gavara
Laurent Gavara
Ludovic Maillard
Ludovic Maillard
JEAN-ALAIN FEHRENTZ
JEAN-ALAIN FEHRENTZ

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