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Back to back publications on self-assembing peptide polymers

Polymerization-Induced Self-Assembly (PISA) concept is based on the chain extension of homopolymers with a co-monomer to yield asymmetric block copolymers. During the chain extension with the second block, self-assembly is induced by the insolubility of the second block in the polymerization solution.

Self-assembling peptides (SAP) are a category of peptides, which undergo spontaneous assembling into ordered nanostructures.

In collaboration with ICGM and IEM institutes were the first to combine both strategies in order to obtain Self-Assembling Peptide—Polymer Nano-Objects via Polymerization-Induced Self-Assembly or SAP-PISA. In a first time SAP-PISA allowed us to obtain a range of original morphologies and macro architectures.

The way is open now for more structural exploration as well as for applications such as drug delivery.

Check more @

Self-Assembling Peptide—Polymer Nano-Objects via Polymerization-Induced Self-Assembly, Dao, L Vezenkov, G Subra, M.Amblard, M In, J-F Le Meins, F Aubrit, M-A Moradi, V Ladmiral, and M. Semsarilar* Macromolecules 2020, 53, 16, 7034–7043, https://doi.org/10.1021/acs.macromol.0c01260

Nano-assemblies with core-forming hydrophobic polypeptide via polymerization-induced self-assembly (PISA), T Dao, L Vezenkov, G Subra, V Ladmiral, M Semsarilar, Polym. Chem., 2020, Advance Article, DOI: 10.1039/D0PY00793E

New paper in European Polymer Journal !

Through a collaboration with the biopolymer team of IBMM , the peptide team describes for the first time the preparation of peptide-nylons hybrids. This novel work add another example of polymer-peptide to the list of studies lead by IBMM peptide team including peptide-silicone, peptide-NCA polymerization and Serine based switchable polymers obtained by ring opening polymerization of lactones.
Special congratulation to all the successive students, post-docs and colleagues who performed this long-lasting experimental work which started in 2016!

Congratulations to Titouan who defended his PhD in February 2020 !

Titouan defended his PhD on February 14, 2020. He presented his work on the design of hybrid hydrogels for biomaterials applications.

New paper in ACS Omega journal !

Titouan, Laurine and Gilles published a paper on 3D sol-gel bioprinting in ACS Oméga journal. This work discribe the design of a multifunctional bioink from silylated HPMC and its bioprinting in the presence of cells during the sol-gel process.

Congratulations to Laurine who defended her PhD in November 2019 !

Laurine Valot finally presented her PhD work on the development of multifunctional hybrid hydrogels for cartilage repair with mesenchymal stem cells encapsulation. Her PhD was supervised by Pr. Gilles SUBRA from the peptide team and Pr. Ahmad MEHDI from Institut Charles Gerhardt in Montpellier.

Laurine presented at the 3rd workshop “Biofabrication & Cancer”

Laurine presented her PhD work and a shared project with Gilles Subra and Pr. Raphael Devillard and Dr. Adrien Naveau from BioTis laboratory in Bordeaux, on Sol-gel chemistry applied to 3D bioprinting: use of extrusion and LIFT-printing for the biofabrication of an oral carcinoma model. The workshop was organized by the Cancéropôle Grand Sud Ouest in September 2019 in Montpellier.

Congratulations to Laurine to published a first paper based on her PhD work !

The first publication of Laurine based on her PhD work has been published in ChemPlusChem.

We demonstrated that sol-gel process is actually a real bio-orthogonal reaction by using a co-catalysis at physiological pH.

See https://onlinelibrary.wiley.com/doi/full/10.1002/cplu.201900509

New paper in Materials Today Communications

Dealing with biorthogonal methods, the bibliography of the PhD of Cécile Echalier is now published as a comprehensive review in Materials Today Communications

See https://www.sciencedirect.com/science/article/pii/S2352492819302107

Congratulations to Laurine and the team for her great review about bioinks!

Congratulations to Laurine and the team for her great review about bioinks! Such a nice work deserved the front cover in Chemical Society Reviews!

See https://pubs.rsc.org/en/content/articlehtml/2019/cs/c7cs00718c

Congratulations Laurine ! New paper in Materials Horizons

The paper of Saïd and Laurine has been published in Materials Horizons

The team disclose the concept of “self-mineralization” : a process by which the self-recognition properties of a peptide sequence (here a simple Phe-Phe pseudodipeptide) triggers the formation of siloxane bonds, leading to a nano structured hybrid materials.

See https://pubs.rsc.org/ko/content/articlehtml/2019/mh/c9mh00580c