We need you! Our team has always open positions for talented and highly motivated students.
Our team has always open positions for talented and highly motivated students.
We accept all applications: from undergraduate students (e.g. 6 months Master fellowships) to PhD applications to take a 3-year exciting journey in one of our upcoming research projects at the frontiers of chemistry and biology.
We also welcome post-doctoral students, especially those interested in preparing applications for European grants such as Marie Curie or willing to apply for a permanent researcher position in our team.
Offre de stage de Master 2, 5 à 6 mois à partir de janvier/février 2021.
Identification of tubulin deglycylase using chemical proteomics
Microtubules (MTs) are hollow tubes formed by the assembly of α- and β-tubulin heterodimers. As a major constituent of the cellular cytoskeleton, they are involved in a number of functions including cell division, intracellular transport and cell morphology. One way to regulate these diverse functions is by changing the MTs properties by posttranslational modifications. Tubulin modifications are currently the subject of an intense research and mostly consist of the addition or removal of various amino acids present on the MTs surface, where they provide the binding sites for various regulatory proteins. The enzymes that catalyze tubulin modifications are either ligases or proteases and most of them have been already identified. During recent years, together with Dr. Rogowski (IGH-Montpellier), we have developed various inhibitors of one of the tubulin modifying enzymes, which catalases detyrosination, a modification implicated in neurodegeneration. A part of this work was recently published (https://doi.org/10.1016/j.celrep.2019.11.074), while a second publication and a patent are now in preparation. The current project is focused on identifying the last unknown enzyme involved in tubulin modifications called tubulin deglycylase. The mission of the internship student will be to synthesis a series of potential deglycylase inhibitors based on the enzyme’s natural substrate. If successful, the inhibitors will be used for affinity purification and identification of tubulin deglycylase. The identification of the deglycylase enzyme would represent a major fundamental discovery that will additionally open the way for different medicinal chemistry applications.
Lieu : Institut de Biomolécules Mas Mousseron (IBMM), Faculté de Pharmacie de Montpellier
Pour candidater, envoyer CV, lettre de motivation et notes de M1