New trisubstituted 1,2,4-triazoles as ghrelin receptor antagonists

Bioorganic & Medicinal Chemistry Letters, 2015, Volume: 25, Issue: 1, Pages: 20-24, DOI: 10.1016/j.bmcl.2014.11.031

A. Blayo, M. Maingot, B. Aicher, C. M’Kadmi, P. Schmidt, G. Muller, M. Teifel, E. Gunther, D. Gagne, S. Denoyelle, J. Martinez, J.-A. Fehrentz


Ghrelin receptor ligands based on a trisubstituted 1,2,4-triazole scaffold were recently synthesized and evaluated for their in vitro affinity for the GHS-R1a receptor and their biol. activity.  In this study, replacement of the α-aminoisobutyryl (Aib) moiety (a common feature present in numerous growth hormone secretagogues described in the literature) by arom. and heteroarom. groups was explored.  We found potent antagonists incorporating the picolinic moiety in place of the Aib moiety.  In an attempt to increase affinity and activity of our lead compd. 2, we explored the modulation of the pyridine ring.  Herein we report the design and the structure-activity relationships study of these new ghrelin receptor ligands.