Chemistry – A European Journal, 2014, Volume: 20, Issue: 44, Pages: 14240-14244, DOI: 10.1002/chem.201404820
C. Martin, B. Legrand, A. Lebrun, D. Berthomieu, J. Martinez, F. Cavelier
The polyproline II helix (PPII) is increasingly recognized as an important element in peptide and protein structures. The discovery of pertinent PPII peptidomimetics is of great interest to tune phys. properties of the targeted structure. A series of silaproline oligomers from dimer to pentamer were synthesized. CD studies, NMR spectroscopy and mol. modeling revealed that the ribbon preferentially populates the polyproline type II secondary structure in both [D]chloroform and [D4]MeOH. The characteristics of this new lipophilic PPII-like helix were detd.