Research Director (CNRS)
Jean-Alain Fehrentz was born in Nancy, France, in 1955. He received his Ph.D. degree in Chemistry from the University of Nancy in 1983 and joined the Centre CNRS-INSERM de Pharmacologie Endocrinologie of Montpellier in the research group of Professor B. Castro. From 1989 to 1992 he was appointed as researcher at Sanofi Research in Montpellier. Then he moved to the Faculty of Pharmacy of Montpellier, working under the direction of Professor J. Martinez.
His research interests focus onpeptide aldehydes, enzyme inhibitors, peptidomimetics, and heterocycle based receptor ligands. He published more than 150 scientific papers.
+33 411 75 96 06
5 major publications
L.S. Chatalic, M. Konijnenberg, J. Nonnekens, E. De Blois, S. Hoeben, C. De Ridder, L. Brunel, J. Martinez, J.-A. Fehrentz, D. C. Van Gent, B. A. Nock, T. Maina, W. M. Van Weerden, M. De Jong; In Vivo Stabilization of GRPR-peptide enhances PET Imaging and Radionuclide Therapy of Prostate Cancer in Preclinical Studies. Theranostics 2016 6 (1), 104-117
G. P. Denis, A. Joly-Amado, E. Webber , F. Langlet,, M. Schaeffer, S. Padilla, C. Cansell, B. Dehouck, J. Castel, A.-S. Delbès, S.Martinez, A. Lacombe, C. Rouch, N. Kassis, J.-A. Fehrentz, J. Martinez, P. Verdié, T. S. Hnasko, R. D. Palmiter, M. Krashes, A. D. Güler, C. Magnan, S. Luquet; Palatability can drive feeding independent of AgRP neurons Cell Metab 2015 22, 4, 646-657
Damian, S. Mary, M. Maingot, C. M’Kadmi, D. Gagne, J-P. Leyris, S. Denoyelle, G. Gaibelet, L. Gavara, M. Garcia De Souza Costa, D. Perahia, E. Trinquet, B. Mouillac, S. Galandrin, C. Gales, J-A. Fehrentz, N. Floquet, J. Martinez, J. Marie, J-L. Baneres; Ghrelin receptor conformational dynamics regulate the transition from a preassembled to an active receptor:Gq complex. PNAS 2015 112 (5) 1601-1606 (2015)
Schaeffer, F. Langlet, C. Lafont, F. Molino, D. J. Hodson, T. Roux, L. Lamarque, P. Verdié, E. Bourrier, B. Dehouck, J.-L. Baneres, J. Martinez, P.-F. Méry, J. Marie, E. Trinquet, J.-A. Fehrentz, V. Prévot, P. Mollard; Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons. PNAS 2013 110(4) 1512-1517
J. -A. Fehrentz, B. Castro; An efficient synthesis of optically active -(t-butoxycarbonylamino)-aldehydes from -amino-acids. Synthesis 1983, vol 8, 676-679