News

6-months internship: PolyPROTAC : implémenter de la multivalence dans la conception d’inducteurs de protéolyse spécifique

Les PROTACs constituent une innovation majeure dans la conception d’agents thérapeutiques. Ces molécules constituées de deux ligands : l’un ciblant une protéine d’intérêt à dégrader, l’autre une ubiquitine E3 ligase (Ub-E3). Elles permettent de détourner le protéasome afin de dégrader spécifiquement une protéine impliquée dans un processus pathologique. Cependant, la conception et le développement de PROTACs restent fastidieux. Notre projet a pour objectif de lever ce verrou en créant le concept de poly-PROTAC. Il s’agira de générer des polymères fonctionnels présentant de multiples copies de molécules PROTAC et ainsi de permettre le multi-recrutement de protéines d’intérêt à dégrader et d’Ub-E3 ligases.

L’étudiant recruté sur ce projet sera impliqué depuis la synthèse et la caractérisation des ligands d’Ub-E3 ligase et de la protéine protéine d’intêret ainsi que dans leur formulation polymérique. La préparation et la caractérisation des polymères ‘polyPROTACs’ sera également au centre des investigations. Enfin, les évaluations biologiques, et notamment l’aptitude des polyPROTACs à dégrader la protéine d’intérêt, seront externalisés.

Domaines : chimie organique de synthèse ; synthèse sur support solide ; chimie des polymères.

Durée du stage : 6 mois, à partir de fin janvier.

New publication in project PEPTIMPRINT!

Development of Amino Acids Functionalized SBA-15 for the Improvement of Protein Adsorption

Molecules 202126(19), 6085; https://doi.org/10.3390/molecules26196085

A new review online! Peptides, polymers, lets bring them together!

After one year of hard work our extensive and exciting review on peptide containing polymers is online! The innovative bottom-up strategies recently developped are at the center of this publication. Have a nice read at https://www.sciencedirect.com/science/article/pii/S0079670021000241

New publication in project PEPTIMPRINT!

SOL-GEL PROCESS – THE INORGANIC APPROACH IN PROTEIN IMPRINTING

J. Mater. Chem. B, 2021 Jan. https://doi.org/10.1016/j.xphs.2020.10.019

IBMM peptide started a new project PEPTIMPRINT!

 The objective of Peptimprint is to set-up a ground-breaking technology to prepare highly specific tridimensional and functionalized imprints of biomolecules (peptides, proteins) by template-assembly, but in this case following the inorganic polymerization by sol-gel process. For that, a variety of original hybrid building blocks mimicking amino acids (diketopiperazine) will be synthetised and developed to be used as precursors (functional monomers) in the MIP synthesis.

Three prizes for the IBMM Peptide PhD students !

Margaux Clavié, Mathilde Guérin and Amandine Sandoval have respectively won the first price of popularizing scientific papers, my thesis in 400 words and best  oral communication during the PhD student congress of Perpignan. Congratulations !!

Back to back publications on self-assembing peptide polymers

Polymerization-Induced Self-Assembly (PISA) concept is based on the chain extension of homopolymers with a co-monomer to yield asymmetric block copolymers. During the chain extension with the second block, self-assembly is induced by the insolubility of the second block in the polymerization solution.

Self-assembling peptides (SAP) are a category of peptides, which undergo spontaneous assembling into ordered nanostructures.

In collaboration with ICGM and IEM institutes were the first to combine both strategies in order to obtain Self-Assembling Peptide—Polymer Nano-Objects via Polymerization-Induced Self-Assembly or SAP-PISA. In a first time SAP-PISA allowed us to obtain a range of original morphologies and macro architectures.

The way is open now for more structural exploration as well as for applications such as drug delivery.

Check more @

Self-Assembling Peptide—Polymer Nano-Objects via Polymerization-Induced Self-Assembly, Dao, L Vezenkov, G Subra, M.Amblard, M In, J-F Le Meins, F Aubrit, M-A Moradi, V Ladmiral, and M. Semsarilar* Macromolecules 2020, 53, 16, 7034–7043, https://doi.org/10.1021/acs.macromol.0c01260

Nano-assemblies with core-forming hydrophobic polypeptide via polymerization-induced self-assembly (PISA), T Dao, L Vezenkov, G Subra, V Ladmiral, M Semsarilar, Polym. Chem., 2020, Advance Article, DOI: 10.1039/D0PY00793E

New paper in European Polymer Journal !

Through a collaboration with the biopolymer team of IBMM , the peptide team describes for the first time the preparation of peptide-nylons hybrids. This novel work add another example of polymer-peptide to the list of studies lead by IBMM peptide team including peptide-silicone, peptide-NCA polymerization and Serine based switchable polymers obtained by ring opening polymerization of lactones.
Special congratulation to all the successive students, post-docs and colleagues who performed this long-lasting experimental work which started in 2016!

Congratulations to Titouan who defended his PhD in February 2020 !

Titouan defended his PhD on February 14, 2020. He presented his work on the design of hybrid hydrogels for biomaterials applications.

New paper in ACS Omega journal !

Titouan, Laurine and Gilles published a paper on 3D sol-gel bioprinting in ACS Oméga journal. This work discribe the design of a multifunctional bioink from silylated HPMC and its bioprinting in the presence of cells during the sol-gel process.