New publication in project APAPTIDE!

One-Pot Synthesis of Bioinspired Peptide-Decorated Apatite Nanoparticles for Nanomedicine

Small 2023, 2306358;

Mathilde Guérin, Aurélien Lebrun, Liisa Kuhn, Thierry Azaïs, Guillaume Laurent, Olivier Marsan, Christophe Drouet and Gilles Subra

Biomimetic apatite nanomaterials stabilized by bioactive peptides are described for the first time in Small.

They were obtained by a ‘one pot’ synthesis developed by Mathilde Guerin, funded by the Carnot Chimie Balard Cirimat Institute. The work was carried out in collaboration between the Peptide team at IBMM and Christophe Drouet’s team at Cirimat with the expertise of the Pole Chimie Balard Analysis platform.

These biomaterials have numerous potential applications in targeted nanomedicine but also for the treatment of complex wounds  and were evaluated by the team of Liisa Kuhn of the university of Connecticut.

New publication in project PEPTIMPRINT!

Development of Amino Acids Functionalized SBA-15 for the Improvement of Protein Adsorption

Molecules 202126(19), 6085;

A new review online! Peptides, polymers, lets bring them together!

After one year of hard work our extensive and exciting review on peptide containing polymers is online! The innovative bottom-up strategies recently developped are at the center of this publication. Have a nice read at

New publication in project PEPTIMPRINT!


J. Mater. Chem. B, 2021 Jan.

IBMM peptide started a new project PEPTIMPRINT!

 The objective of Peptimprint is to set-up a ground-breaking technology to prepare highly specific tridimensional and functionalized imprints of biomolecules (peptides, proteins) by template-assembly, but in this case following the inorganic polymerization by sol-gel process. For that, a variety of original hybrid building blocks mimicking amino acids (diketopiperazine) will be synthetised and developed to be used as precursors (functional monomers) in the MIP synthesis.

Three prizes for the IBMM Peptide PhD students !

Margaux Clavié, Mathilde Guérin and Amandine Sandoval have respectively won the first price of popularizing scientific papers, my thesis in 400 words and best  oral communication during the PhD student congress of Perpignan. Congratulations !!

Back to back publications on self-assembing peptide polymers

Polymerization-Induced Self-Assembly (PISA) concept is based on the chain extension of homopolymers with a co-monomer to yield asymmetric block copolymers. During the chain extension with the second block, self-assembly is induced by the insolubility of the second block in the polymerization solution.

Self-assembling peptides (SAP) are a category of peptides, which undergo spontaneous assembling into ordered nanostructures.

In collaboration with ICGM and IEM institutes were the first to combine both strategies in order to obtain Self-Assembling Peptide—Polymer Nano-Objects via Polymerization-Induced Self-Assembly or SAP-PISA. In a first time SAP-PISA allowed us to obtain a range of original morphologies and macro architectures.

The way is open now for more structural exploration as well as for applications such as drug delivery.

Check more @

Self-Assembling Peptide—Polymer Nano-Objects via Polymerization-Induced Self-Assembly, Dao, L Vezenkov, G Subra, M.Amblard, M In, J-F Le Meins, F Aubrit, M-A Moradi, V Ladmiral, and M. Semsarilar* Macromolecules 2020, 53, 16, 7034–7043,

Nano-assemblies with core-forming hydrophobic polypeptide via polymerization-induced self-assembly (PISA), T Dao, L Vezenkov, G Subra, V Ladmiral, M Semsarilar, Polym. Chem., 2020, Advance Article, DOI: 10.1039/D0PY00793E

New paper in European Polymer Journal !

Through a collaboration with the biopolymer team of IBMM , the peptide team describes for the first time the preparation of peptide-nylons hybrids. This novel work add another example of polymer-peptide to the list of studies lead by IBMM peptide team including peptide-silicone, peptide-NCA polymerization and Serine based switchable polymers obtained by ring opening polymerization of lactones.
Special congratulation to all the successive students, post-docs and colleagues who performed this long-lasting experimental work which started in 2016!

Congratulations to Titouan who defended his PhD in February 2020 !

Titouan defended his PhD on February 14, 2020. He presented his work on the design of hybrid hydrogels for biomaterials applications.

New paper in ACS Omega journal !

Titouan, Laurine and Gilles published a paper on 3D sol-gel bioprinting in ACS Oméga journal. This work discribe the design of a multifunctional bioink from silylated HPMC and its bioprinting in the presence of cells during the sol-gel process.

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