Laurent Gavara

Laurent Gavara
associate professor, ENSM

Laurent Gavara completed his M. Sci. in 2005 in Montpellier and pursued his graduate studies under the supervision of Pr. Jean-Pierre Hénichart and Pr. Benoit Rigo at the University of Lille, where he received his Ph.D. in 2008. He conducted a first postdoctoral work for 2 years in Clermont-Ferrand in the Pascal Moreau group and then moved to a second postdoctoral position for 1 year in Fort Worth, US, with the Pr. Jean-Luc Montchamp. In 2012, he joined the group of Muriel Amblard at the faculty of pharmacy of Montpellier as research fellow. One year later, he reached an associate professor position in the same group. His research interests are focused on the design and the synthesis of small heterocyclic molecules. He is currently working to fight the bacterial resistance thank to the inhibition of key bacterial enzymes.

Contact:

laurent.gavara@umontpellier.fr

+33 (0)4 11 75 96 03

5 major publications :

L. Sevaille, L. Gavara, C. Bebrone, F. De Luca, L. Nauton, M. Achard, P. Mercuri, S. Tanfoni, L. Borgianni, C. Guyon, P. Lonjon, G. Turan-Zitouni, J. Dzieciolowski, K. Becker, L. Bénard, C. Condon, L. Maillard, J. Martinez, J.-M. Frère, O. Dideberg, M. Galleni, J.-D. Docquier, J.-F. Hernandez, 1,2,4-Triazole-3-thione compounds as inhibitors of di-zinc metallo-β-lactamases. ChemMedChem. 2017 just accepted

M. Damian, S. Mary, M. Maingot, C. M’Kadmi, D. Gagne, J.-P. Leyris, S. Denoyelle, G. Gaibelet, L. Gavara, M. Garcia de Souza Costa, D. Perahia, E. Trinquet, B. Mouillac, S. Galandrin, C. Galès, J.-A. Fehrentz, N. Floquet, J. Martinez, J. Marie, J.-L. Baneres, Ghrelin receptor conformational dynamics regulate the transition from a preassembled to an active receptor:Gq complex. Proc. Natl. Acad. Sci. 2015, 5, 1601

F. Gelat, C. Lacomme, O. Berger, L. Gavara, J.-L. Montchamp, Synthesis of (phosphonomethyl)phosphinate pyrophosphate analogues via the phospha-Claisen condensation. Org. Biomol. Chem. 2015, 13, 825

V. Suchaud, L. Gavara, F. Giraud, L. Nauton, V. Théry, F. Anizon, P. Moreau, Synthesis of pyrazolo[4,3-a]phenanthridines, a new scaffold for Pim kinase inhibition. Bioorg. Med. Chem. 2014, 22, 4704

V. Suchaud, L. Gavara, E. Saugues, Nauton, V. Théry, F. Anizon, P. Moreau, Identification of 1,6-dihydropyrazolo[4,3-c]carbazoles and 3,6-dihydropyrazolo[3,4-c]carbazoles as new Pim kinase inhibitors. Bioorg. Med. Chem. 2013, 21, 4102