Professor, Faculty of Pharmacy, University OF MONTPELLIER
Alain Chavanieu received his Ph.D. degree in Biochemistry from the University of Montpellier in 1992. After a post-doctoral period at the University of Birmingham (U.K.) in the group of Pr Barry Levine, he joined the Centre de Biochimie Structurale of Montpellier from 1985 to 2002 as post doctoral fellow then as associate professor. In 2011, he moved to the Institut des biomolecules Max Mousseron at the Faculty of Pharmacy of Montpellier, under the direction of Professor J. Martinez. His research interests focus on structure function of proteins and modulation of protein-protein interactions.
+33 411 75 95 27
5 major publications :
Fragment-based identification of a locus in the Sec7 domain of Arno for the design of protein-protein interaction inhibitors. Rouhana J, Hoh F, Estaran S, Henriquet C, Boublik Y, Kerkour A, Trouillard R, Martinez J, Pugnière M, Padilla A, Chavanieu A. J Med Chem. 2013 Nov 14;56(21):8497-511. doi: 10.1021/jm4009357. Epub 2013 Oct 29.
Kinetics of interaction between ADP-ribosylation factor-1 (Arf1) and the Sec7 domain of Arno guanine nucleotide exchange factor, modulation by allosteric factors, and the uncompetitive inhibitor brefeldin A. Rouhana J, Padilla A, Estaran S, Bakari S, Delbecq S, Boublik Y, Chopineau J, Pugnière M, Chavanieu A. J Biol Chem. 2013 Feb 15;288(7):4659-72. doi: 10.1074/jbc.M112.391748. Epub 2012 Dec 19.
Structure-based discovery of an inhibitor of Arf activation by Sec7 domains through targeting of protein-protein complexes. Viaud J, Zeghouf M, Barelli H, Zeeh JC, Padilla A, Guibert B, Chardin P, Royer CA, Cherfils J, Chavanieu A. Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10370-5. Epub 2007 Jun 11.
Change in membrane permeability induced by protegrin 1: implication of disulphide bridges for pore formation. Mangoni ME, Aumelas A, Charnet P, Roumestand C, Chiche L, Despaux E, Grassy G, Calas B, Chavanieu A. FEBS Lett. 1996 Mar 25;383(1-2):93-8.
Involvement of phosphoinositide 3-kinase in insulin- or IGF-1-induced membrane ruffling. Kotani K, Yonezawa K, Hara K, Ueda H, Kitamura Y, Sakaue H, Ando A, Chavanieu A, Calas B, Grigorescu F, et al. EMBO J. 1994 May 15;13(10):2313-21.