Structure based drug design

We develop several projects related to the characterization and inhibition of molecular interactions between proteins and protein-ligand.

Based on molecular modeling studies of protein-protein or protein-ligand interactions, our first step is to design pharmacophore constraints to orient the design of putative inhibitor candidates. In collaboration with chemists, the most suitable scaffold (foldamer, chemical molecule and peptide) is selected and candidates are synthetized. Then, after purification of functional proteins, we carry out protein-protein and protein-ligand interaction studies by biophysics to evaluate the inhibitory potency of compounds.

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