Several projects in medicinal chemistry deal with enzyme inhibition. Enzymes play central roles in all life processes and in some circumstances, their inhibition can help resolve pathological situations. In most diseases, if not all, it is possible to propose at least one enzyme as a potential target, and many drugs are enzyme inhibitors. Enzymes could be human enzymes that can be inhibited to treat various diseases as cardio-vascular, inflammatory, cancer and neurological diseases. Enzymes can also be exogenous ones that are essential for the life of deadly virus, bacteria or parasites.
We have a long time experience in the design of enzyme inhibitors and we are currently investigating the following medicinal targets:
– NO Synthases
– Metallo-β-lactamases (MBL) and the bacterial resistance to β-lactam antibiotics
– HslVU, a proteasome-like complex present in the mitochondria of Trypanosomatids
– Cancers with overexpression of the lysosomal Cathepsin D (CathD)
– Kallikrein inhibitors
– New antimelanoma agents